Mel Tucker and the Michigan State Spartans host the Western Michigan Broncos in a season-opening matchup at 7 p.m. ET on Friday. Michigan State is favored by 21 points at Caesars Sportsbook, while the over/under is set at 54 (see up-to-date odds for every game this week on our college football odds page). 

Before making any Western Michigan vs. Michigan State picks, you NEED to check out the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,600 for $100 players on its top-rated college football picks against the spread. It enters Week 1 of the 2022 college football season on a 45-32 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen huge returns.

The model knows Western Michigan is coming off a strong 2021 campaign. The Broncos won eight games, the highest total for the program since 2016. Western Michigan also won its most recent game against a Power 5 opponent, upsetting Pittsburgh on the road last season, and the Broncos should benefit from Michigan State's loss of All-American running back Kenneth Walker. 

The model also knows that Michigan State is on a 12-game winning streak against Western Michigan, with a great deal of returning production. Michigan State quarterback Payton Thorne set a new school record with 27 touchdown passes last season, and he is also a dual threat with 322 non-sack rushing yards in 2021.

Now, it has set its sights on Western Michigan vs. Michigan State. We can tell you the model is leaning Over the total, and it also says one side of the spread hits in over 50% of simulations! You ABSOLUTELY need to see it before locking in any college football picks.

Who wins Western Michigan vs. Michigan State? And which side of the spread hits in over 50% of simulations? ... Join SportsLine right now to find out which side of the Western Michigan vs. Michigan State spread you should be all over Friday, all from the model on a roll on college football picks!