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USC vs. Stanford odds, line, spread: Proven model reveals college football picks, predictions for Week 2, 2021

The SportsLine projection model has simulated Stanford vs. USC and revealed its college football picks
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A Pac-12 battle is on tap between the USC Trojans and the Stanford Cardinal at 10:30 p.m. ET on Saturday at United Airlines Field at the Los Angeles Memorial Coliseum. The Trojans (1-0) ended last year first in the Pac-12 South Division, while the Cardinal (0-1) ended up third in the Pac-12 North Division. 

The Trojans are 17-point favorites in the latest USC vs. Stanford odds from Caesars Sportsbook, and the over-under is set at 52.5. Before you make any Stanford vs. USC picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of over $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 2 of the 2021 season on a 63-45 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, it has simulated USC vs. Stanford 10,000 times and the results are in. We can tell you that the model is leaning over on the point total, and it's also generated a point-spread pick that is hitting in 60 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins USC vs. Stanford? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks... If you're already a member, see the picks below!

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SportsLine Staff