Fan favorite Anthony "Lionheart" Smith looks to work back toward title contention Saturday when he faces rising contender Ryan Spann in the main event of UFC Fight Night. The main card is set for 7 p.m. ET from the Apex facility in Las Vegas.

The No. 6-ranked Smith (35-16) is a one-time title challenger who is pushing toward another title run after his March 2019 loss to former champion Jon Jones sent him on a downward slide in which in he lost three of four, with two coming in lopsided fashion. But he has built some momentum by scoring wins over lower-level prospects in his last two fights.

Smith looks to see more resistance from the No. 11-ranked Spann (19-6), a former Legacy Fighting Alliance champion who believes he is being overlooked in the vast mix of light heavyweight prospects. A win over Smith would move him into the top-10 rankings and raise his profile with MMA observers. 

Smith is a -165 favorite (risk $165 to win $100), while Spann comes back at +145 (risk $100 to win $145) in the latest Caesars Sportsbook odds for UFC Fight Night: Smith vs. Spann. 

Before making any picks for UFC Fight Night: Smith vs. Spann, you need to see the UFC predictions from SportsLine MMA expert Brandon Wise. He specializes in picking main-card fights for UFC, which has enabled him to be profitable every year! 

In fact, Wise called for a submission win by Vicente Luque (+220) over fellow grappling specialist Michael Chiesa at UFC 265. His other notable recent selections include calling middleweight champion Israel Adesanya by decision at +140 against challenger Marvin Vettori and Brandon Moreno to win outright at +190 for the flyweight title at UFC 263 earlier this summer. Wise also went a perfect 5-0 at UFC 239 and was 4-1 at both UFC 245 and UFC 249.

Now, with UFC Fight Night: Smith vs. Spann fast approaching, Wise has carefully studied every main-card matchups and the available props and released his MMA predictions. 

For UFC Fight Night: Smith vs. Spann, we can tell you Wise is backing Joaquin Buckley (-210) to get past Antonio Arroyo (+180) in a battle of middleweight prospects on the main card. 

Wise also has strong picks for Spann vs. Smith and every other bout on the UFC Fight Night main card. He's also backing one combatant in "a fight that just screams mismatch" to take a dominant victory! You ABSOULTELY must see his picks before locking in your plays!

Who wins Smith vs. Spann? And what other fighters provide the most value in the MMA odds? ... Join SportsLine now to see which fighters you need to be all over at UFC Fight Night, all from the accomplished MMA analyst who has been profitable for six straight years!