The second-seeded Creighton Bluejays take on the third-seeded Connecticut Huskies in a 2021 Big East Conference Tournament semifinal on Friday. Tip-off from Madison Square Garden in New York is set for 9 p.m. ET. William Hill Sportsbook lists the Bluejays as 1.5-point favorites, while the Over-Under for total points scored is 143.5 in the latest UConn vs. Creighton odds (see up-to-date lines for every game on our college basketball odds page). 

Before making any UConn vs. Creighton picks, you NEED to check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past four-plus years, the proprietary computer model has generated an impressive profit of over $2,600 for $100 players on its top-rated college basketball picks against the spread. It has also returned over $400 on all top-rated college basketball picks this season. Anyone who has followed it has seen HUGE returns.

Now, it has set its sights on UConn vs. Creighton. We can tell you the model is leaning Over the total, and it also says one side of the spread hits well over 50 percent of the time! You ABSOLUTELY need to see it before locking in any college basketball picks.

Who wins UConn vs. Creighton? And which side of the spread hits well over 50 percent of the time? ... Join SportsLine right now to find out which side of the UConn vs. Creighton spread you should be all over Friday, all from the model on a roll on college basketball picks!