The lead in the American Athletic Conference will be on the line when the Memphis Tigers host the Tulane Green Wave in a key AAC showdown on Friday at Simmons Bank Liberty Stadium in Memphis. The Green Wave (4-1, 1-0 in AAC) entered the season as the preseason favorite to win the conference title. Meanwhile, the Tigers (4-1, 1-0), who were picked fourth in the AAC in the preseason, are coming off a 35-32 comeback victory over Boise State on Sept. 30.

Kickoff is scheduled for 7 p.m. ET. The Green Wave are 5-point favorites in the latest Tulane vs. Memphis odds, while the over/under for total points scored is 55. Tulane is the -206 favorite on the money line. (See up-to-date odds for every game this week on our college football odds page.)

Before you make any Memphis vs. Tulane picks, you need to see the college football predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Since its inception, it has generated a stunning profit of more than $2,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

The model knows that the Green Wave have a gamebreaker in Jha'Quan Jackson. A 5-foot-11 senior from Luling, La., Jackson is averaging 23.6 yards per catch this season, which leads the conference and ranks eighth in the nation. He also is seventh in the country in yards per punt return (15.2).

The model also knows that Liberty Stadium has been a difficult place for visiting teams to play. Since Ryan Silverfield was elevated to head coach in December 2019, the Tigers are 19-4 at Liberty Stadium. Memphis also has won the last eight meetings against Tulane at home, a stretch that began in the 2002 season.

Now, the model has set its sights on Tulane vs. Memphis. We can tell you it is leaning Over the total, and it also says one side of the spread hits in well over 50% of simulations! You ABSOLUTELY need to see it before locking in any college football picks.

Who wins Memphis vs. Tulane, and which side of the spread hits in well over 50% of simulations? ... Join SportsLine right now to find out which side of the Tulane vs. Memphis spread you should be all over Friday, all from the model that's up nearly $2k on top-rated CFB picks since its inception!