Today's picks: Why Colts will cover vs. 49ers, plus more NFL, college football, Red Sox vs. Astros ALCS Game 6 and college football picks for Friday, October 22

Jonathan Coachman is joined by top betting experts Allie O' Neill, Allan Bell and Larry Hartstein on the Early Edge podcast, powered by SportsLine. Get prime plays for the the NFL, college football, Game 6 of the ALCS and NHL for Friday, Oct. 22.

Allan opens by disclosing some unique trends on Tom Brady as a double-digit favorite. Larry looks at shifting odds in the AFC West, and the Coach expresses his concerns about Titans WR A.J. Brown, who is battling an illness. 

Under heavy pressure, the Coach supplies the SportsLine Play of the Day, which is Colorado State and Utah State Under 58.5 points at 9:30 p.m. ET. He also shares Justin Perri's ALCS Game 6 pick of the Astros -111 over the Red Sox at 8:08 p.m. ET. 

Allie's featured NHL selection is the Stars -150 over the Kings at 8:30 p.m. ET. Both goalies are playing well, but the edge goes to the Stars in their home opener.  

Allan is on Memphis -2 over UCF at 7 p.m. ET. The Knights are 0-5 ATS so far this season and Memphis has the momentum coming off a good win last week. He also drops an interesting tidbit about the Tennessee-Alabama matchup on Saturday at 7 p.m. ET. 

Larry is going with the Colts +4 over the 49ers on Sunday at 8:20 p.m. ET. "The 49ers are off a bye, I know Jimmy G is coming back, but (left tackle) Trent Williams has not practiced at all," he says. Larry stresses that not having Williams and Trey Lance creates a very adverse situation for San Francisco. "The Colts have turned it around. This offense looks good, 83 points in the last three games. Carson Wentz has six TDs and no interceptions in the last three games and he's healthy." 

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