Week 1 of the 2021 NFL season sees two AFC giants collide when the Buffalo Bills host the Pittsburgh Steelers on Sunday at 1 p.m. ET. Buffalo is a 6.5-point favorite in the latest Steelers vs. Bills odds from Caesars Sportsbook, while the over-under is 48.

Sunday's showdown will be televised on CBS and streamed live in select markets on Paramount+ with their MUST-HAVE Premium plan. Plus, you can watch games on ANY device!

You can catch all your local NFL on CBS games on Paramount+, which now has two plans. The Essential Plan costs $4.99 per month to access Paramount's catalog of movies and TV shows with limited advertisements, plus your live local NFL games, international soccer and more. The Premium Plan is $9.99 per month and you can watch your local CBS live stream with no ads, on demand and the ability to download episodes for offline viewing. Both plans come with a free week to start, so sign up now here.

Before making any Bills vs. Steelers picks or any other NFL predictions, you NEED to see what the SportsLine Projection Model has to say.

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters the 2021 season on an incredible 120-78 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the Top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP.

Now, it has simulated Steelers vs. Bills 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that hits in over 50 percent of simulations. You ABSOLUTELY need to see it before locking in your own picks. And don't forget you may be able to stream the game on Paramount+ on ANY DEVICE!

Who wins Steelers vs. Bills? And which side of the spread hits over 50 percent of the time? ... Join SportsLine right now to see which side of the Bills vs. Steelers spread to jump on, all from the model that has crushed its NFL picks!