Southern Miss vs. Louisiana prediction, odds, line, spread, start time: Advanced college football computer model releases picks, best bets for Week 11 matchup

The Louisiana Ragin' Cajuns (5-4) host the Southern Miss Golden Eagles (2-7) in a Sun Belt Conference battle Thursday at 7:30 p.m. ET. The Ragin' Cajuns are 8.5-point favorites according to the latest Southern Miss vs. Louisiana odds via SportsLine consensus, while the over/under for total points scored is 52.5 (see up-to-date odds for every game this week on our college football odds page). 

Before making any Southern Miss vs. Louisiana picks, you NEED to check out the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Since its inception, it has generated a stunning profit of well over $2,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen HUGE returns.

The model knows Louisiana freshman quarterback Zeon Chriss is a very impactful player in both the run and pass game. The Louisiana native has 1,222 passing yards, 492 rushing yards and 17 total scores. Last week against Arkansas State, Chriss racked up 187 scrimmage yards and two total scores.

The model also knows Southern Miss junior running back Frank Gore Jr. continues to be a patient runner with great contact balance. Gore Jr. has 163 carries, 812 rushing yards and seven touchdowns. On Oct. 28 versus Appalachian State, Gore Jr. finished with a season-high 247 yards and two scores. 

Now, the model has set its sights on Southern Miss vs. Louisiana. We can tell you the model is leaning Under the total, and it also says one side of the spread hits more than 60% of the time! You ABSOLUTELY need to see it before locking in any college football picks.

Who wins Southern Miss vs. Louisiana, and which side of the spread hits more than 60% of the time? ... Join SportsLine right now to find out which side of the Southern Miss vs. Louisiana spread you should be all over Thursday, all from the model that's up more than $2,000 on top-rated CFB spread picks since its inception!