South Carolina vs. Kentucky odds, line, spread: Proven model reveals college football picks, predictions for Week 4, 2021

The South Carolina Gamecocks and the Kentucky Wildcats square off in a key SEC East matchup at 7 p.m. ET on Saturday at Williams-Brice Stadium. South Carolina is coming off a lopsided 40-13 loss to Georgia last weekend, but Kentucky is looking to keep its undefeated season going.

The Gamecocks are 2-1 overall and 1-0 at home, while UK is 3-0 overall but playing in its first road game. The Wildcats are first in the East, and South Carolina is at the bottom of the division after last week. The Wildcats are favored by five points in the latest South Carolina vs. Kentucky odds from Caesars Sportsbook, and the over-under is set at 48.5. Before you make any Kentucky vs. South Carolina picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. It also enters Week 4 of the 2021 season on a 72-58 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, it has simulated South Carolina vs. Kentucky 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins South Carolina vs. Kentucky? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks ... If you're already a member, see the picks below!