Cincinnati and St. Louis will open their three-game series on Friday night. The Cardinals had won four out of their last five games prior to Thursday's 5-0 loss in Miami, while the Reds have now lost nine straight games. It is Cincinnati's longest losing streak in five years. The Reds are also the only National League team ever to lose nine consecutive games in which they had seven or fewer hits in each game. First pitch at Great American Ball Park is set for 6:40 p.m. ET.

St. Louis is listed as a -125 favorite (risk $125 to win $100) on the money line in the latest Cardinals vs. Reds odds from Caesars Sportsbook, while the over-under for total runs scored is 7.5 (see the latest lines for every game on our MLB odds page).

Before making any Reds vs. Cardinals picks, you NEED to see the latest MLB predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a sizzling start to the 2022 season. It's on a 14-4 roll on top-rated MLB money-line picks through two weeks, returning over $800 for $100 players. Anyone following it has seen HUGE returns!

The model knows that the Reds are bound to bounce back from this losing streak soon. They have star youngster Hunter Greene on the mound for this game. The rookie has 13 strikeouts and just two walks through his first two starts this season, throwing a fastball that routinely breaks 100 mph. Greene has an advantage against a St. Louis lineup that has never faced him. He has made it through five innings in each of his first two starts in the majors, despite having to face two of the best lineups in baseball (Braves, Dodgers). 

The model also knows St. Louis is playing much better baseball right now. The Cardinals have won four of their last six games this season, and they have won five of the last seven meetings between these teams. Third baseman Nolan Arenado went 3 of 4 against Miami on Thursday, which came a day after he hit a game-winning home run in the ninth inning. Left-handed pitcher Steven Matz is 1-0 with a 3.38 ERA and 14 strikeouts in 13.1 career innings against Cincinnati. The Reds are dealing with multiple key injuries, including Jonathan India, Mike Moustakas and Tyler Stephenson.  

Now, it has set its sights on Reds vs. Cardinals. We can tell you the model is projecting 9.3 total runs, and it also says one side of the money line has all the value! You ABSOLUTELY need to see it before locking in any MLB picks of your own.

So who wins Reds vs. Cardinals? And which side of the money line has all the value? ... Join SportsLine right now to find out which side of the Cardinals vs. Reds money line you should be all over on Friday, all from the model on a roll on MLB picks!