The No. 4 Ohio State Buckeyes and the No. 19 Purdue Boilermakers take the field in Columbus at 3:30 p.m. ET on Saturday. Ohio State is favored by 20 points at Caesars Sportsbook, while the Over-Under is set at 65 (see up-to-date odds for every game this week on our college football odds page). 

Before making any Purdue vs. Ohio State picks, you NEED to check out the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 11 of the 2021 season on a 31-20 run on all top-rated college football side picks. Anyone who has followed it has seen HUGE returns.

The model knows Purdue has strengths on both sides of the ball. The Boilermakers are averaging more than 400 yards of total offense per game, including the No. 2 passing offense in the Big Ten. Purdue leads the conference in completing 70.5 percent of passes, and the Boilermakers are strong on third down, converting at a 44.6 percent clip. Purdue also allows only 18.4 points per game defensively, with more interceptions (11) than touchdown passes allowed (seven) during the 2021 season.

The model also knows Ohio State is virtually unstoppable on offense. The Buckeyes are leading the Big Ten in scoring 44.9 points per game, and that figure ranks No. 2 in the country. Ohio State is also No. 1 in the Big Ten in averaging 541.8 total yards per game, No. 3 in the country, and No. 1 in the conference in passing offense, averaging 352.8 yards per game. Ohio State averages 10.0 yards per pass attempt with 27 touchdown passes, and the Buckeyes have allowed only six interceptions and 11 sacks in 2021.

Now, it has set its sights on Purdue vs. Ohio State. We can tell you the model is leaning under the total, and it also says one side of the spread hits in well over 50 percent of simulations! You ABSOLUTELY need to see it before locking in any college football picks.

Who wins Purdue vs. Ohio State? And which side of the spread hits in well over 50 percent of simulations? ... Join SportsLine right now to find out which side of the Purdue vs. Ohio State spread you should be all over Saturday, all from the model on a roll on college football picks!