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Purdue vs. Notre Dame line, predictions: Advanced computer college football model releases picks for non-conference matchup

SportsLine's projection model generated selections for Saturday's non-conference matchup between the Purdue Boilermakers and Notre Dame Fighting Irish
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The 10th-ranked Notre Dame Fighting Irish meet the Purdue Boilermakers in a key non-conference matchup on Saturday as coach Brian Kelly looks for win No. 105 to tie legendary Knute Rockne for most wins all-time by a Notre Dame football coach. Both Notre Dame and Purdue are 2-0 on the year. 

Kickoff from Notre Dame Stadium in South Bend, Ind., is set for 2:30 p.m. ET. Notre Dame is favored by 7.5 points at Caesars Sportsbook, while the Over-Under is set at 58.5 (see up-to-date odds for every game this week on our college football odds page). 

Before making any Purdue vs. Notre Dame picks, you NEED to check out the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of over $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 3 of the 2021 season on a 67-50 run on all top-rated college football picks. Anyone who has followed it has seen HUGE returns.

Now, it has set its sights on Purdue vs. Notre Dame. We can tell you the model is leaning Under the total, and it also says one side of the spread hits in almost 60 percent of simulations! You ABSOLUTELY need to see it before locking in any college football picks.

Who wins Purdue vs. Notre Dame? And which side of the spread hits in almost 60 percent of simulations? ... Join SportsLine right now to find out which side of the Purdue vs. Notre Dame spread you should be all over Saturday, all from the model on a roll on college football picks!

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SportsLine Staff