The Pittsburgh Pirates meet the Chicago Cubs in the second of a four-game weekend series in a National League Central matchup on Friday afternoon. The Pirates (28-42), who have won five of the past seven games, are 9-23 on the road this season. The Cubs (42-27), who have lost five of nine, are 21-11 on their home field in 2025.

First pitch from Wrigley Field in Chicago is set for 2:20 p.m. ET. The Cubs have won seven of the past 10 meetings with the Pirates. Chicago is a -117 favorite on the money line (risk $117 to win $100) in the latest Pirates vs. Cubs odds from DraftKings Sportsbook, while Pittsburgh is at -103. The total number of runs Vegas thinks will be scored, or the over/under, is 6.5 in the latest MLB odds. 

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The model has simulated Pirates vs. Cubs 10,000 times and the results are in. We can tell you the model is going Over on the run total, and it also says one side of the money line has all the value!

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