The Philadelphia Phillies return to the postseason for the first time in 11 years when they face the St. Louis Cardinals on Friday in Game 1 of their best-of-three National League Wild Card Series. Philadelphia (87-75) finished third in the highly-competitive NL East, which saw three teams make the postseason. St. Louis (93-69) won the NL Central Division title, overtaking Milwaukee in August and coasting to its first division crown in three years.

First pitch at Busch Stadium in St. Louis is set for 2:07 p.m. ET. Both teams are listed at -110 (risk $110 to win $100) on the money line in the latest Phillies vs. Cardinals odds from Caesars Sportsbook, while the over/under for total runs scored is 6.5 (see the latest lines for every game on our MLB odds page).

Before making any Phillies vs. Cardinals picks, you NEED to see the latest MLB predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it entered the final week of the regular season on an 18-8 run on top-rated money-line picks, returning almost $700 for $100 players. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win it all last season. Anybody who has followed it has seen HUGE returns.

The model knows Paul Goldschmidt is the pace-setter for St. Louis, batting .317 with 35 homers, 115 RBI and 106 runs scored. He was 2-for-4 with a double and two RBI in a division-clinching 6-2 win at Milwaukee on Sept. 27. In seven games against Philadelphia this season, Goldschmidt was 6-for-24 (.250) with a pair of doubles. In 65 career games against the Phillies, he is batting just .249, but has cranked out 14 doubles, one triple and nine home runs. He has also stolen four bases.

The model also knows Philadelphia will send right-hander Zack Wheeler (12-7, 2.82 ERA) to the mound. Wheeler has won four of his last six decisions, and has 163 strikeouts and just 34 walks this season. In Wheeler's last appearance, an 8-1 win at Washington on Sunday, he allowed just two hits, while striking out seven in five innings. He has dominated St. Louis this season, going 2-0 against the Cardinals. In 14 innings of work, he has allowed nine hits, two walks and 10 strikeouts with zero runs crossing the plate.

Now, it has set its sights on Phillies vs. Cardinals. We can tell you the model is leaning Over on the total, and it also says one side of the money line has ALL the value! You ABSOLUTELY need to see it before locking in any MLB picks of your own.

So who wins Phillies vs. Cardinals? And which side of the money line has ALL the value? ... Join SportsLine right now to find out which side of the Phillies vs. Cardinals run line you should be all over on Friday, all from the model on a roll on MLB picks!