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Patriots vs. Bills game line, MNF odds: NFL picks, predictions for Week 13 AFC East matchup from proven model

The SportsLine Projection Model has simulated Patriots vs. Bills 10,000 times and revealed its Week 13 NFL picks
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The AFC East title race is close and the division's two frontrunners will face off on Monday Night Football. The New England Patriots (8-4) will visit the Buffalo Bills (7-4) in hopes of extending their six-game winning streak. On the other hand, the hosts have lost two games over the last four weeks. 

Buffalo is a three-point favorite in Caesars Sportsbook's latest Patriots vs. Bills odds, while the Over-Under for total points is 40.5. Kickoff at Highmark Stadium is set for 8:15 p.m. ET.

Before you make any Patriots vs. Bills picks, you NEED to check out the latest NFL predictions from the SportsLine Projection Model. 

The model, which simulates every NFL game 10,000 times, is up almost $7,100 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 14 of the 2021 season on an incredible 131-94 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP!

The model knows New England's run defense is impregnable. The Patriots have allowed a league-low six rushing touchdowns. Only the Tennessee Titans have tallied a rushing score against the Patriots over the last four weeks, and the Bills haven't found the end zone on the ground in two weeks. 

The model also knows the Bills entered Week 13 having allowed a league-low 3,027 passing yards. Opposing teams have tallied a league-low eight passing touchdowns against Buffalo.

Now, the model has broken down the Patriots vs. Bills matchup and revealed its results. We can tell you it's leaning under on the point total, and it also says one side of the spread hits in well over 50 percent of simulations! You ABSOLUTELY need to see it before locking in any Patriots vs. Bills picks of your own.

So who wins Patriots vs. Bills on Monday Night Football? And which side of the spread hits in well over 50 percent of simulations? ... Join SportsLine right now to see which side of the Patriots vs. Bills spread to back, all from the dialed-in NFL model that's up almost $7,100 on top-rated picks!

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SportsLine Staff