Packers vs. Bills odds, line, spread: 2021 NFL preseason picks, Week 3 predictions from proven Packers expert

The final week of this year's preseason is around the corner, and 14 teams will begin the weekend with games on Saturday. The Green Bay Packers will visit the Buffalo Bills in Saturday's first game, with kickoff at Highmark Stadium set for 1 p.m. ET. The Bills are 9.5-point favorites in the latest Packers vs. Bills odds at Caesars Sportsbook, and the Over-Under is 37. 

Before making any Packers vs. Bills picks or any other NFL predictions, you NEED to see what Green Bay expert R.J. White has to say. 

White, a Fantasy and gambling editor for CBS Sports, ended the 2020 season on an 80-59 run on all NFL picks, returning more than $1,400 during that span. It's no surprise, as White has cashed huge twice in the world's most prestigious football handicapping competition, the Las Vegas SuperContest.

White is also on a 43-12 (+$2,927) run on his last 56 picks involving Green Bay. Anyone who has followed him is WAY UP.

We can tell you that White is leaning over the total in this matchup, but his much stronger play is on the spread. He has also discovered a critical X-factor that has him jumping all over one side of the spread! You ABSOLUTELY need to see it before locking in your own picks.

Who wins Packers vs. Bills? And what critical X-Factor makes one side of the spread hit hard? ... Join SportsLine right now to see which side of the Packers vs. Bills spread to jump on, all from the expert who's on an outstanding 43-12 run on Packers picks!