The Green Bay Packers will look for their second consecutive win and first one on the road when they take on the San Francisco 49ers in a key NFC matchup on Sunday Night Football. Kickoff at Levi's Stadium in Santa Clara, Calif., is set for 8:20 p.m. ET. The 49ers are favored by 3-points in the latest Packers vs. 49ers odds from Caesars Sportsbook, while the over-under is 50.5.

After a dismal opening week which saw him throw a pair of interceptions, quarterback Aaron Rodgers rebounded in typical fashion on Monday night, passing for 255 yards and four TDs. He became just the third quarterback (Tom Brady and Drew Brees) with 25 or more games with four or more touchdown passes and no interceptions.

San Francisco, meanwhile, has had a lot of success against Green Bay in the past, including tight end George Kittle. Kittle had six catches for 129 yards and a touchdown in his last game against the Packers in November 2019. He has also played well on Sunday Night Football with 35 receptions (8.8 per game) for 507 yards (126.8 per game) and three receiving touchdowns in four career games.   

Before you make any Packers vs. 49ers picks or any other NFL predictions, you NEED to see which side Sportsline NFL expert R.J. White is on. 

White, a CBS Sports fantasy and gambling editor, ended the 2020 season on an 80-59 run on all NFL picks, returning more than $1,400 during that span. It's no surprise, as White has cashed huge twice in the world's most prestigious football handicapping competition, the Las Vegas SuperContest. In addition, White is 43-13 on his last 56 against the spread picks involving the Packers! Anyone who has followed him is WAY UP!

Now, White has locked in another confident against the spread pick for Packers vs. 49ers. We can tell you he's leaning over, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins Packers vs. 49ers on Sunday Night Football? And what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the Packers vs. 49ers spread to jump on, all from the expert who's an outstanding 43-13 on picks involving the Packers!