Ole Miss vs. Louisville odds, line, spread: Proven model reveals college football picks, predictions for Week 1, 2021

The Ole Miss Rebels will take on the Louisville Cardinals at 8 p.m. ET on Monday at Mercedes-Benz Stadium. The Rebels ended last year fifth in the West Division, while U of L ended up 11th in the Atlantic Division. The Rebels are favored by 10 points in the latest Ole Miss vs. Louisville odds from Caesars Sportsbook, and the over-under is set at 75.5. Before you make any Louisville vs. Ole Miss picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of over $3,600 for $100 players on its top-rated college football picks against the spread. It also enters Week 1 of the 2021 season on a 57-37 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, it has simulated Ole Miss vs. Louisville 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in almost 60 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Ole Miss vs. Louisville? And which side of the spread is a must-back? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks...If you're already a member, see the picks below!