Ohio State vs. Michigan State odds, prediction: 2026 men's college basketball picks for Feb. 22 from proven model

Longtime Big Ten rivals will meet on Sunday on CBS and Paramount+ (sign up here) when the Michigan State Spartans host the Ohio State Buckeyes. No. 15 MSU (21-5, 11-4 Big Ten) has alternated wins and losses over its last four and is coming off a Tuesday victory over UCLA. The Buckeyes (17-9, 9-6 Big Ten) have alternated wins and losses over their last nine games, most recently defeating Wisconsin on Feb. 17. Michigan State leads the all-time series with 44 wins versus 23 losses.

Tipoff is at 1 p.m. ET from the Breslin Center in East Lansing, Mich. The Spartans are 9.5-point favorites in the latest Ohio State vs. Michigan State odds, while the over/under for total points scored is 147.5.

Before making any Michigan State vs. Ohio State college basketball picks, check out the latest college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and entered Week 16 on a sizzling 11-1 run on top-ranked over/under picks dating back to last year, and is on a 13-7 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated Ohio State vs. Michigan State 10,000 times and the results are in. The model is going Over, and it also says one side of the spread hits almost 60% of the time!

So who wins Michigan State vs. Ohio State, and which side of the spread hits in almost 60% of simulations? Join SportsLine right now to see which side of the Ohio State vs. Michigan State spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!