Ohio State vs. Akron odds, line, spread: Proven model reveals college football picks, predictions for Week 4, 2021

The Akron Zips take a swing at the No. 10 Ohio State Buckeyes at 7:30 p.m. ET on Saturday at Ohio Stadium. Ohio State shook off a tough loss to No. 3 Oregon in Week 2 take down Tulsa 41-20 last Saturday. Akron has yet to win a FBS game this season, but would love to upset one of the nation's top programs.

Ohio State is in the midst of an early four-way tie in the Big Ten East, and next week the Buckeyes get back into conference play against Rutgers. OSU is favored by 49 points in the latest Ohio State vs. Akron odds from Caesars Sportsbook, and the over-under is set at 67.5. Before you make any Akron vs. Ohio State picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. It also enters Week 4 of the 2021 season on a 72-58 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, it has simulated Ohio State vs. Akron 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in almost 60 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Ohio State vs. Akron? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks... If you're already a member, see the picks below!