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The No. 5 Indiana Hoosiers and Northwestern Wildcats, both unbeaten in non-conference action, get their Big Ten Conference slates started on Friday night. Indiana (3-0) has whipped its three opponents by an average of 43 points. Northwestern (2-0) challenged itself a little more but was impressive in double-digit wins over South Dakota State and Colorado. The Hoosiers and Wildcats average 461 and 460 yards per game, respectively. Claim the latest Polymarket promo code SPORTSLINE to get a $50 trading bonus after a $10 deposit:
Kickoff is set for 8 p.m. ET at Memorial Stadium in Bloomington, Ind. The Hoosiers are 21-point favorites in the latest Northwestern vs. Indiana odds. The over/under for total points is 49.5.
Before making any Northwestern vs. Indiana picks, check out the college football predictions from the SportsLine Projection Model.
The model simulates every FBS game 10,000 times. It is off to a profitable 22-19 start on all top-rated college football picks so far this season, and it has been upgraded for the 2026 season to better factor in the transfer portal!
The model has simulated Northwestern vs. Indiana 10,000 times and the results are in. The model is going Under on the total, and it also says one side of the spread hits in nearly 60% of simulations!
So who wins Northwestern vs. Indiana, and which side of the spread hits nearly 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that is on a 22-19 run on top-rated CFB picks!
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