North Carolina vs. Syracuse odds, prediction: 2026 Atlantic Coast Conference men's college basketball picks from proven model

Teams looking to get back on track meet when the No. 16 ranked North Carolina Tar Heels face the Syracuse Orange in a key Atlantic Coast Conference matchup on Saturday. North Carolina is coming off an 82-58 loss at North Carolina State on Tuesday, while Syracuse dropped a 101-64 decision at Duke on Monday. The Tar Heels (20-6, 8-5 ACC), who are tied for sixth in the conference, are 3-5 on the road this season. The Orange (15-12, 6-8 ACC), who are tied for 11th, are 12-4 on their home floor. Caleb Wilson (fractured hand) is expected to miss the game for UNC.

Tipoff from JMA Wireless Dome in Syracuse, N.Y., is set for 1 p.m. ET. North Carolina leads the all-time series 19-7, including an 87-77 win on Feb. 2. North Carolina is a 1.5-point favorite in the latest North Carolina vs. Syracuse odds from DraftKings Sportsbook, while the over/under for total points scored is 154.5. 

Before making any North Carolina vs. Syracuse picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and entered Week 16 on a sizzling 11-1 run on top-ranked over/under picks dating back to last year, and is on an 13-7 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated North Carolina vs. Syracuse 10,000 times and the results are in. The model is leaning Under, and it also says one side of the spread hits well over 60% of the time!

So who wins UNC vs. Syracuse, and which side of the spread hits well over 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!