The North Carolina Tar Heels will take on the No. 24 Michigan Wolverines at 9:15 p.m. ET on Wednesday at the Dean E. Smith Center in the 2021 ACC/Big Ten Challenge. Both teams are 4-2 but the Tar Heels are 3-0 at home, while Michigan is 1-0 on the road. 

The Wolverines are favored by 2.5 points in the latest North Carolina vs. Michigan odds from Caesars Sportsbook, and the over-under is set at 151. Before you make any Michigan vs. North Carolina picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $2,100 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, it has simulated North Carolina vs. Michigan 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in over 50 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins North Carolina vs. Michigan? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks... If you're already a member, see the picks below!