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North Carolina State vs. Clemson prediction, odds, line: Advanced college football model reveals picks for Saturday's matchup

SportsLine's projection model has generated Week 5 CFB picks for the contest between the 10th-ranked North Carolina State Wolfpack and fifth-ranked Clemson Tigers
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The fifth-ranked Clemson Tigers look to continue their home dominance over the No. 10 North Carolina State Wolfpack when they meet in Atlantic Coast Conference action on Saturday. The Tigers (4-0) will look to push their all-time record at Memorial Stadium against N.C. State to 24-11 since the facility opened in 1942. Clemson coach Dabo Swinney is 10-2 all-time against the Wolfpack (4-0), including 5-0 in home games. This will be the conference opener for North Carolina State, while Clemson is 2-0 in ACC play.

Kickoff from Clemson, S.C., is set for 7:30 p.m. ET. Clemson is a 6.5-point favorite in the latest North Carolina State vs. Clemson odds from Caesars Sportsbook, while the over/under for total points scored is 45.5. (See up-to-date odds for every game this week on our college football odds page.) 

Before you make any North Carolina State vs. Clemson picks or college football predictions, you NEED to see the predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of more than $3,100 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen HUGE returns!

The model knows Clemson junior quarterback DJ Uiagalelei has been on a tear. In last week's 51-45 double-overtime win over No. 21 Wake Forest, he completed 26 of 41 passes (63.4 percent) for 371 yards and five touchdowns. He has thrown nine TDs over the past three weeks. For the season, Uiagalelei has completed 83 of 129 passes (64.3 percent) for 1,033 yards and 10 touchdowns vs. one interception.

The model also knows North Carolina State is led by redshirt junior quarterback Devin Leary. Leary has been sharp, connecting on 64 percent of his passes, completing 80 of 125 for 890 yards and nine touchdowns. He has thrown for two interceptions, but has a rating of 144.4. Last week, Leary was on fire, connecting on 32 of 44 passes (72.7 percent) for 320 yards and four touchdowns in a 41-10 win over Connecticut.

Now, the model has set its sights on North Carolina State vs. Clemson. We can tell you it is leaning Over the total, and it also says one side of the spread hits in more than 60% of simulations! You ABSOLUTELY need to see it before locking in any college football picks.

Who wins North Carolina State vs. Clemson? And which side of the spread hits more than 60% of the time? ... Join SportsLine right now to find out which side of the North Carolina State vs. Clemson spread you should be all over Saturday, all from the model on a roll on college football picks!

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SportsLine Staff

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