The fourth-ranked Oregon Ducks will look to open their Big Ten season on a high note when they face the Northwestern Wildcats on Saturday. Oregon is coming off a 69-3 pasting of Oklahoma State, while Northwestern cruised to a 42-7 win over Western Illinois in Week 2. The Ducks (2-0), who won the Big Ten regular-season title at 9-0 last year and finished 13-1, were 5-0 on the road in 2024. The Wildcats (1-1), who placed 16th in the conference at 2-7 and 4-8 overall, were 2-4 on their home field.

Kickoff from Martin Stadium in Evanston, Ill., is at noon ET. Northwestern won the only previous meeting with Oregon, earning a 14-10 win in 1974. The Ducks are 26.5-point favorites in the latest Oregon vs. Northwestern odds, while the over/under for total points scored is 48.5 via SportsLine consensus.

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The model has simulated Oregon vs. Northwestern 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread is the better value!

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