The No. 22 Iowa State Cyclones kick off their 2025 season against the Big 12 rival No. 17 Kansas State Wildcats in a Week 0 matchup in Ireland on Saturday, Aug. 23. Iowa State shared the regular-season Big 12 championship, while Kansas State shared eighth-place in the conference with West Virginia. The Wildcats (5-4, 9-4), who were 2-1 against ranked opponents a year ago, had a plus-97 point differential. The Cyclones (11-3, 7-2), who were 9-2 against unranked foes, were plus-114 in point differential. This is the first ranked matchup between these programs since 2002.

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Kickoff is set for noon ET at Aviva Stadium in Dublin, Ireland. Iowa State leads the all-time series 54-50-4, including a 29-21 win last season. The Wildcats are 3-point favorites in the latest Iowa State vs. Kansas State odds, while the over/under for total points scored is 51. Kansas State is the -164 favorite (risk $164 to win $100) on the money line, with ISU at +138.

Before making any Kansas State vs. Iowa State picks or college football predictions, you NEED to hear what SportsLine college football expert Josh Nagel has to say.

Nagel is a Nevada-based handicapper with more than 25 years of experience in the sports wagering industry. SportsLine's assistant managing editor has covered the wagering industry on a variety of platforms and has won numerous sports handicapping contests. He finished 2023 on an 11-2 run to wrap up a season that provided a profit of more than $1,500 to SportsLine members. He's 8-0 (+850) in his last eight picks in games involving the Wildcats. Anyone who has followed him is WAY up!

Now, Nagel has analyzed Kansas State vs. Iowa State from every angle and just locked in his picks and predictions.

We can tell you he's leaning Over on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins Iowa State vs. Kansas State on Saturday, Aug. 23? And what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the Kansas State vs. Iowa State spread to jump on, all from the football expert who is 8-0 (+850) on his last eight Kansas State picks!

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