The Indiana Hoosiers will look to derail the second-ranked Purdue Boilermakers when they meet in a key Big Ten Conference matchup on Tuesday at 7 p.m. ET from Simon Skjodt Assembly Hall in Bloomington, Ind. The Boilermakers are 15-2 overall and 4-2 in Big Ten play, while the Hoosiers are 12-5 and 4-2. Purdue is favored by 9.5 points in the latest Purdue vs. Indiana odds, and the over/under is 150 points.

Before entering any Purdue vs. Indiana picks, you'll want to see the NCAA Basketball predictions from the model at SportsLine.

The model simulates every Division I college basketball game 10,000 times. It enters Week 11 of the 2023-24 season on a 110-73 roll on all top-rated college basketball picks dating back to last season, returning more than $2,000 for $100 players. It is also off to a sizzling 15-5 start on top-rated spread picks this season. Anyone following has seen HUGE returns!

The model knows Purdue senior center Zach Edey, the 2022-23 NCAA Player of the Year, is coming off a monster effort in Saturday's win over Penn State. He scored 30 points, grabbed 20 rebounds, dished out three assists and blocked three shots. It was his 10th double-double of the season. He also had a 35-point and 14-rebound effort in a 92-88 overtime loss at Northwestern on Dec. 1. For the season, he is averaging 22.3 points, 10.9 rebounds, 2.3 blocks and 1.8 assists in 29.1 minutes of action.

It is also aware the Hoosiers have four players scoring 10 points or more per game, led by sophomore forward Malik Reneau. He has started all 17 games for Indiana this season, averaging 16.3 points, 5.8 rebounds and 3.1 assists in 29.1 minutes of action. He is coming off a 16-point and six-rebound performance in Friday's win over Minnesota.

The model has simulated Purdue vs. Indiana 10,000 times and the results are in. We can tell you that the model is leaning Under, and it also says one side of the spread hits well over 50% of the time!

So who wins Purdue vs. Indiana, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that is on a 110-73 roll on its top-ranked college basketball picks!