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Top 25 teams face off in a Big Ten Conference showdown as the No. 18 Michigan Wolverines host the No. 17 Iowa Hawkeyes in a Week 4 matchup Saturday. It's the first Big Ten game for either side. Michigan (3-0) made up for its struggles vs. Western Michigan by beating 11th-ranked Oklahoma, while Iowa edged Rival 16-13 and blanked its other two opponents. The Wolverines have won four straight in this series, the last meeting coming in the 2023 Big Ten Championship game. Claim the latest Polymarket promo code SPORTSLINE to get a $50 trading bonus after a $10 deposit:
Kickoff is set for 3:30 p.m. ET at Michigan Stadium in Ann Arbor, Mich. The Wolverines are 5.5-point favorites in the latest Iowa vs. Michigan odds. The over/under for total points is 38.5. Michigan is the -218 favorite on the money line.
Before making any Iowa vs. Michigan picks, check out the college football predictions from the SportsLine Projection Model.
The model simulates every FBS game 10,000 times. It is off to a profitable 22-19 start on all top-rated college football picks so far this season, and it has been upgraded for the 2026 season to better factor in the transfer portal!
The model has simulated Iowa vs. Michigan 10,000 times and the results are in. The model is going Over on the total, and it also says one side of the spread hits in well over 50% of simulations!
So who wins Iowa vs. Michigan, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that is on a 22-19 run on top-rated CFB picks!
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