Content on this page may include affiliate links. If you click and sign up/place a wager, we may receive compensation at no cost to you.
Old Pac-12 rivals face off in an important Big Ten showdown when the No. 20 Oregon Ducks host the No. 12 USC Trojans on Saturday night. USC (4-0) is also 1-0 in the conference after edging Rutgers 42-35 last week in New Jersey. It's the first Big Ten game for Oregon (2-1), who rebounded from a surprising 39-31 loss to Oklahoma State by pummeling Portland State 84-0. The Ducks have won the last four meetings, including last year's 42-27 in Eugene. Claim the latest Polymarket promo code SPORTSLINE to get a $50 trading bonus after a $10 deposit:
Kickoff is set for 7:30 p.m. ET at Memorial Coliseum in Los Angeles. The Ducks are 3-point favorites in the latest Oregon vs. USC odds, down from -5.5 earlier in the week. The over/under for total points is 62.5. Oregon is the -161 favorite on the money line.
Before making any Oregon vs. USC picks, check out the college football predictions from the SportsLine Projection Model.
The model simulates every FBS game 10,000 times. It is off to a profitable 22-19 start on all top-rated college football picks so far this season, and it has been upgraded for the 2026 season to better factor in the transfer portal!
The model has simulated Oregon vs. USC 10,000 times and the results are in. The model is going Under on the total, and it also says one side of the spread hits in nearly 60% of simulations!
So who wins Oregon vs. USC, and which side of the spread hits nearly 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that is on a 22-19 run on top-rated CFB picks!
Don't miss out: All new SportsLine memberships include Paramount+ Premium -- a $13.99/month value -- for no extra cost! Join now and get it all.
GET VEGAS EXPERT PICKS FOR NFL, MLB, NBA, CBB, GOLF, NHL, HORSE RACING AND MORE - PLUS ADVANCED COMPUTER SIMULATIONS, WINNING TOOLS, AND MORE!
