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There are five divisional games on Sunday, and common matchups could certainly help making Week 5 NFL score predictions. Seahawks vs. 49ers is one of those, with Seattle having a discernible scoring trend. It scored 13 points in both regular season matchups last season, as the Seahawks have scored exactly 13 points in four of their last seven meetings with San Fran in the regular season. If you expect that NFL trend to continue, then you're halfway to nailing a Week 5 NFL exact score bet. Claim the latest Polymarket promo code SPORTSLINE to get a $25 trading bonus after a $10 deposit:
There are trends like that for every team in every game, with 49ers vs. Seahawks one of seven games with an NFL spread of a field goal or less, and observing history could make your Week 5 NFL predictions all the easier.
SportsLine expert Eric Cohen has made his exact Week 5 NFL score predictions for every matchup. Before you lock in any NFL picks, make sure you see what Cohen has to say.
A SportsLine expert and host, Cohen is evaluating the entire Week 5 NFL slate and delivers score predictions and logic for each matchup. Last season, Cohen went 188-96-1 (66%) on straight-up NFL picks and is 38-26 (59%) in the 2026 NFL season.
We can tell you that Cohen likes the Texans (-7, 38.5) to defeat the Titans, while the Under also hits. "Shockingly, this is a matchup of 0-4 teams whose seasons effectively end with a fifth straight loss. The downfall of Houston defensively is shocking. But fortunately, they face a really bad Tennessee offense on Sunday so maybe this is their get right spot. Also, eight of the last ten meetings between these two franchises have seen 37 or less points. Expect a low-scoring, ugly game with the Texans starting their long road back to .500 with a two-score win." Texans 22, TITANS 13
In addition, Cohen has identified EIGHT games where the team with the worse record notches a victory! Nailing these results is key to making profitable Week 5 NFL picks. You ABSOLUTELY NEED to see which games they are before locking in any Week 5 NFL score predictions!
Who wins every Week 5 NFL game, and which eight teams get huge wins? ... Join SportsLine now to get Eric Cohen's Week 5 NFL score predictions and find out today!
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Written by Ross Kelly
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