NFL Week 10 best bets: Five top picks for against the spread pools and contests target ugly Dolphins-Colts game
With the trade deadline now in the past, some teams head into Week 10 with adjustments that need to be made


The trade deadline and a rash of injuries have wreaked havoc on several rosters coming into Week 10, particularly at the receiver position. The Colts, Cardinals and Rams suddenly have questions about who the No. 1 receiver is, with injuries to Puka Nacua and Michael Wilson as well as the Colts trading their two most notable receivers. Quarterback change is also impacting lines around the league, with Kirk Cousins and Jacoby Brissett starting for new teams, plus Kyle McCord and Carson Beck stepping in for injured starters.
The Jaguars made big moves at the deadline but are giving new defensive stars Jordan Davis and Jesse Bates a bye week. The Bills are up against an inconsistent Jets team with the offensive firepower to make noise when things are clicking. The Seahawks are still starting Drew Lock and are dealing with multiple absences on the offensive line, including trade acquisition Quenton Nelson. We already covered the Rams. Those are the four biggest favorites of the week, and all are on the road, with all but Seattle playing divisional games. Can any of them be trusted? Can you have faith in any of the teams they're playing?
Our best bets this week primarily focus on games with shorter spreads, including the must-watch Dolphins-Colts matchup. Let's get into them now.
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