NFL odds, lines, spreads: 2026 Wild Card Weekend NFL picks, predictions from proven model

After 272 regular season games, the 2026 NFL playoffs have arrived, starting with Wild Card Weekend. Seven teams that made the postseason as wild cards have eventually won the Super Bowl, so one shouldn't bypass those squads when making Wild Card Weekend NFL picks. Houston is riding a league-high eight-game win streak, while the Bills may be the most experienced team in the AFC. The Texans are 3.5-point road favorites versus Pittsburgh, per the latest Wild Card NFL odds, while the Bills are favored by 1.5 points as they'll visit Jacksonville.

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There are also a couple of NFC teams you could make Wild Card NFL bets on that could become the eighth non-divisional winner to win the Super Bowl. The 5-seed Rams have championship pedigree as they'll visit Carolina (+10.5) in a game which has the largest of the Wild Card NFL spreads. Meanwhile, the 49ers have the added incentive of San Francisco hosting Super Bowl LX as they'll match up with the Eagles (-3.5). The other games of the weekend are Packers vs. Bears (-1) and Patriots vs. Chargers (+3.5).

Before locking in any NFL bets, make sure you see what SportsLine's advanced computer model has to say. 

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters the 2026 NFL playoffs on a 53-37 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!

Now, the model has evaluated the latest NFL odds, simulated every snap for Wild Card Weekend of the 2026 NFL playoffs, and the results are in.

We can tell you one of the model's strongest Wild Card Weekend NFL picks is that the Steelers (+3.5, 39.5) cover at Houston on Monday night at 8 p.m. ET. The model has Pittsburgh prevailing versus the spread over 50% of the time, and it also says the Over hits in well over 50% of simulations.

The model has also made the call on who wins and covers in every other NFL game this week and just revealed THREE teams projected to win in over 60% of simulations! You ABSOLUTELY NEED to see its NFL picks for every game before you make any NFL bets of your own!

So which NFL teams should you back in Wild Card Weekend, and which three teams should you lock in RIGHT NOW? ... Join SportsLine now to see who wins and covers every single NFL game this week, all from the model on 53-37 roll on top-rated NFL picks!

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