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As we saw with the game in Australia to start the year, travel and body clock are things to keep in mind when making NFL picks. The Week 3 NFL schedule is one ripe with contests that could be affected by travel, including a pair of West Coast teams having 1 p.m. ET kickoffs on the East Coast. The Chargers will visit the Bills, with Buffalo 7-point favorites per the Week 3 NFL odds, while the Seahawks will visit the Commanders, where Seattle is a 6.5-point road favorite. But no one will travel quite like Dallas and Baltimore as they'll meet in Rio de Janeiro, Brazil, where the Ravens are at -3 to target with NFL bets. Claim the latest Polymarket promo code SPORTSLINE to get a $50 trading bonus after a $10 deposit:
The biggest of the Week 3 NFL spreads has Kansas City as 11.5-point road favorites at Miami. Meanwhile, the slimmest of the NFL lines has Houston favored by 1.5 points at Indianapolis.
Before locking in any NFL bets, make sure you see what SportsLine's advanced computer model has to say.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 3 of the 2026 NFL season on a 53-41 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!
Now, the model has evaluated the latest NFL odds, simulated every snap for Week 3 of the 2025 NFL season, and the results are in.
We can tell you one of the model's strongest Week 3 NFL picks is that the Lions (-6.5, 47.5) cover versus the Jets in a Sunday 1 p.m. ET kickoff. The model has Detroit prevailing versus the spread well over 60% of the time. Another one of its Week 3 NFL predictions: the 49ers (-8.5, 47.5) cover versus the Cardinals at home. San Fran is forecasted to cover the spread in well over 50% of simulations, with the Over almost 60% of the time.
The model has also made the call on who wins and covers in every other NFL game this week and just revealed FIVE A-rated spread picks, potentially providing a huge payday! You ABSOLUTELY NEED to see its NFL picks for every game before you make any NFL bets of your own!
So which NFL teams should you back in Week 3, and which five A-rated picks should you lock in RIGHT NOW? ... Join SportsLine now to see who wins and covers every single NFL game this week, all from the model on a 53-41 roll on top-rated NFL picks!
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Written by Ross Kelly
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