Friday's full 16-game MLB slate features a highly anticipated series opener between the MLB-best New York Yankees and the heavy-hitting Toronto Blue Jays. New York has won seven straight and is 47-16 (.746), the only team in the big leagues with a winning percentage above .650. Aaron Judge has been on fire for the Yankees and already has 25 home runs, seven more than any other player. Vlad Guerrero, meanwhile, has 16 for Toronto, as both teams average more than one homer per game. There are some other intriguing  battles, with St. Louis visiting Boston for an interleague matchup and Houston hosting the White Sox in a rematch of their 2021 American League Division Series. 

New York is a -120 favorite on the money line in the latest Yankees vs. Blue Jays odds from Caesars Sportsbook. Toronto is a +100 underdog, while the Over/Under for runs scored is 9.5. First pitch is set for 7:07 p.m. ET from Toronto. With a full slate of games, there are tons of options for you to cash in on wagers, and if you combine them in a parlay, you can hit big. (See up-to-date lines for every game on our MLB odds page.)

Before you make any MLB picks or parlays, be sure to see the predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a strong start to the 2022 season. It's on a 55-42 roll on top-rated MLB money-line picks through 10 weeks, returning more than $600 for $100 players. Anyone following it has seen huge returns.

Now, the model has set its sights on the MLB schedule for Friday, June 17. Using its top picks for the day, the model has generated a four-leg parlay that would pay more than 14-1! The parlay doesn't start until 7:07 p.m. ET, giving you plenty of time to make your MLB picks.

We can tell you that one of the picks is Under 9.5 runs (-120) in that Yankees-Blue Jays showdown! But the model has three other picks, including two CONFIDENT  plays! You ABSOLUTELY need to see them before locking in any MLB picks of your own.

So which lines have value and can help you cash in BIG Friday ninght? And which underdogs are MUST-BACKS for a parlay with a payout of more than 14-1? ... Join SportsLine right now to find out which picks you should be all over on Friday, all from the model that is on a 55-42 roll on top-rated MLB money-line picks through 10 weeks!