The 2022 MLB regular season comes to a close on Wednesday with 16 afternoon games, including the Los Angeles Angels and Oakland A's squaring off with the Angels' two-way star Shohei Ohtani taking the mound at Oakland Coliseum. The reigning American League MVP, Ohtani ranks fourth in the AL in both home runs (34) and ERA (2.35).

Los Angeles is a -225 favorite in the latest Angels vs. A's odds from Caesars Sportsbook, while Oakland is a +185 underdog. The over/under for runs scored is 6.5. The game is one of 16 on the MLB schedule for Wednesday. (See up-to-date lines for every game on our MLB odds page.)

Before making any MLB picks or parlays, be sure to see the predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it entered the penultimate week of the regular season on a 14-3 run on top-rated money-line picks, returning almost $900 for $100 players. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win the World Series. Anybody who has followed the model has seen huge returns.

Now, the model has set its sights on the MLB schedule for Wednesday, Oct. 5, and has generated a four-leg parlay that would pay 14-1! The parlay doesn't start until 4 p.m. ET, giving you plenty of time to make your MLB picks.

We can tell you that one of the picks is the Yankees (-110) to beat the Rangers. But the model has three other picks, including a play on a big American League underdog! You ABSOLUTELY need to see them before locking in any MLB picks of your own.

So which AL underdog is a MUST-BACK? And what other teams do you need to include in your parlay for a payout of 14-1? ... Join SportsLine right now to find out which picks you should be all over on Wednesday, all from the model that is on a 14-3 run on top-rated money-line picks!