The 2023 MLB regular season commences on Thursday with games across the country, including the reigning World Series champion Houston Astros hosting the Chicago White Sox in an Opening Day matchup at Minute Maid Park in Houston. Framber Valdez (17-6, 2.82 ERA) takes the mound for the Astros, while Dylan Cease (14-8, 2.2) will start for the White Sox.

Houston is a -160 favorite in the latest Astros vs. White Sox odds from Caesars Sportsbook, while Chicago is a +135 underdog. The over/under for runs scored is 7. The game is one of 15 on the MLB schedule for Opening Day. (See up-to-date lines for every game on our MLB odds page.)

Before making any MLB picks or parlays, be sure to see the predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times. It went 331-285 on top-rated MLB money-line picks (+357) over the past two seasons, and it finished the 2022 MLB season on a 20-14 roll. Anybody who has followed the model has seen profitable returns.

Now, the model has set its sights on the MLB schedule for Opening Day and has generated a four-leg parlay that would pay almost 15-1! The parlay doesn't start until 4 p.m. ET, giving you plenty of time to make your MLB picks.

We can tell you that one of the picks is the Phillies (+115) to beat the Rangers. But the model has three other picks, including a play on an even bigger underdog! You ABSOLUTELY need to see them before locking in any MLB picks of your own.

So which big underdog is a MUST-BACK? And what other teams do you need to include in your parlay for a payout of almost 15-1? ... Join SportsLine right now to find out which picks you should be all over on Opening Day, all from the model that is on a 20-14 run on top-rated money-line picks!