Two division leaders collide when the Chicago White Sox host the St. Louis Cardinals in the second game of a three-game series on Tuesday. The White Sox are -135 money-line favorites in the latest White Sox vs. Cardinals odds from William Hill Sportsbook, while the Cardinals are +125 underdogs. First pitch is at 8:10 p.m. ET.

The game is one of 15 on Tuesday's loaded MLB schedule. (See up-to-date lines for every game on our MLB odds page.)

Before entering any MLB picks or parlays, you NEED to see the latest predictions from the SportsLine Projection Model. 

This model, which simulates every pitch of every game 10,000 times, had a banner 2019 season, the league's last full schedule, returning more than $1,400 on its top-rated money-line and run-line picks. It is off to a fast start in 2021, going 61-44 on top-rated MLB money-line picks through eight weeks, returning well over $700. Anyone following it has seen HUGE rewards.

Now, the model has set its sights on the MLB schedule for Tuesday. Using its top picks for the day, the model has generated a four-leg parlay that would pay more than 12-1! The best part is that the parlay doesn't start until 7:10 p.m. ET, giving you plenty of time to make your MLB picks!

We can tell you that one of the picks is the Red Sox (+101) to beat the Braves. But the model has three other picks, including an even bigger American League underdog pulling off an upset! You ABSOLUTELY need to see it before locking in any MLB picks of your own.

So which American League underdog is a MUST-BACK? And what other teams do you need include in your parlay for a 12-1 payout? ... Join SportsLine right now to find out which picks you should be all over on Tuesday, all from the model that is off to a fast start in 2021!