Two of the best teams in baseball collide when the San Francisco Giants host the Oakland A's at Oracle Park in San Francisco. First pitch is 9:45 p.m. ET. The A's are -111 money-line favorites in the latest A's vs. Giants odds from William Hill Sportsbook, while the Giants are +101 underdogs. 

The game is one of 16 on Friday's loaded MLB schedule. (See up-to-date lines for every game on our MLB odds page.)

Before entering any MLB picks or parlays, you NEED to see the latest predictions from the SportsLine Projection Model. 

This model, which simulates every pitch of every game 10,000 times, had a banner 2019 season, the league's last full schedule, returning more than $1,400 on its top-rated money-line and run-line picks. It's off to a sizzling start in 2021, going 100-74 on top-rated MLB money-line picks through 12 weeks, returning more than $1,200. Anyone following it has seen HUGE returns!

Now, the model has set its sights on the MLB schedule for Friday. Using its top picks for the day, the model has generated an EPIC four-leg parlay that would pay more than 10-1! The best part is that the parlay doesn't start until 7:10 p.m. ET, giving you plenty of time to make your MLB picks!

We can tell you that one of the picks is the Indians (+115) to beat the Twins at 8:10 p.m. ET. But the model has three other picks, including an American League underdog pulling off a big upset! You ABSOLUTELY need to see it before locking in any MLB picks of your own.

So which American League underdog is a MUST-BACK? And what other teams do you need to include in your parlay for a 10-1 payout? ... Join SportsLine right now to find out which picks you should be all over on Friday, all from the model that is off to a fast start in 2021!