Two of the top teams in baseball renew their rivalry when the Houston Astros take on the San Francisco Giants in the first of a three-game interleague series on Friday. First pitch from Oracle Park in San Francisco is set for 9:45 p.m. ET. San Francisco is listed at -125 on the money line (risk $125 to win $100) in the latest Astros vs. Giants odds from William Hill Sportsbook.

The contest is one of 15 on the MLB schedule for Friday evening. (See up-to-date lines for every game on our MLB odds page.)

Before entering any MLB picks or parlays, you NEED to see the latest predictions from the SportsLine Projection Model. 

This model, which simulates every pitch of every game 10,000 times, is a profitable 132-109 on top-rated MLB money-line picks through 17 weeks in the 2021 season. It also had a banner 2019 season, the league's last full schedule, returning more than $1,400 on its top-rated money-line and run-line picks. Anyone following it has seen some HUGE returns!

Now, the model has set its sights on the MLB schedule for Friday. Using its top picks for the day, the model has generated a four-leg parlay that would pay well over 16-1! The best part is that the parlay doesn't start until 7:10 p.m. ET, giving you plenty of time to make your MLB picks!

We can tell you that one of the picks is the Chicago White Sox (-210) to beat the Cleveland Indians (8:10 p.m. ET). But the model has three other picks, including multiple big underdog plays! You ABSOLUTELY need to see them before locking in any MLB picks of your own.

So which underdogs are MUST-BACKS? And what other teams do you need to include in your parlay for a payout of well over 16-1? ... Join SportsLine right now to find out which picks you should be all over on Friday, all from the model that is a profitable 132-109 this season!