MLB DFS, 2026: Top FanDuel, DraftKings picks, lineups, advice for Wednesday, July 22, from a daily Fantasy pro

The Wednesday MLB schedule features 17 games, including a pair of doubleheaders, but the main MLB DFS slate consists of nine games starting at 6:40 p.m. ET or later. Among those within the MLB DFS player pool are Junior Caminero, Matt Olson, Pete Crow-Armstrong and Yordan Alvarez. Big names like those come with hefty price tags on daily Fantasy baseball sites, so you'll have to look for bargains elsewhere to complete your Wednesday MLB DFS lineups.

Before making any MLB DFS picks on sites like DraftKings and FanDuel for this slate, you need to see what Mike McClure has to say.

McClure is a DFS professional with over $2 million in career winnings. He's also a predictive data engineer at SportsLine who uses a powerful prediction model that simulates every minute of every game 10,000 times, taking factors like matchups, statistical trends and injuries into account.

This allows him to find the best MLB DFS values and create optimal lineups that he shares only at SportsLine. They're a must-see for any MLB DFS player.

For Wednesday, one of McClure's top MLB DFS picks is Yankees second baseman Jazz Chisholm ($4,300 DraftKings, $3,200 FanDuel). He's also building his MLB DFS lineups around Rays outfielder Chandler Simpson ($3,500 DraftKings, $2,700 FanDuel). Chandler has a scorching bat with four hits in Tuesday's game and nine total hits over his last four contests.

McClure is also targeting a player who could go off for massive numbers on Wednesday! This pick could be the difference between winning your tournaments and cash games or going home with nothing. You absolutely need to see who it is before locking in any lineups.

What are the top MLB DFS picks for Wednesday? ... Join SportsLine now to see DFS pro Mike McClure's top picks, stacks, and player pools for FanDuel and DraftKings, and cash in BIG on MLB DFS!