Missouri vs. Central Michigan odds, line, spread: Proven model reveals college football picks, predictions for Week 1, 2021

The Missouri Tigers will take on the Central Michigan Chippewas at 4 p.m. ET Saturday at Memorial Stadium at Faurot Field. The Tigers ended last year third in the East Division, while CMU ended up fourth in the West Division. The Tigers are favored by 15 points in the latest Missouri vs. Central Michigan odds from Caesars Sportsbook, and the over-under is set at 60.5. 

Before making any Central Michigan vs. Missouri picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of over $3,600 for $100 players on its top-rated college football picks against the spread. It also enters Week 1 of the 2021 season on a 57-37 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, it has simulated Missouri vs. Central Michigan 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in almost 70 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Missouri vs. Central Michigan? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks ... If you're already a member, see the picks below!