Michigan vs. Florida State odds, lines: Proven model reveals college basketball picks for the 2021 NCAA Tournament Sweet 16 game

The seedings held to form in only one Sweet 16 matchup and that one features the No. 1 seed Michigan Wolverines squaring off with the fourth-seeded Florida State Seminoles in the East Region of the NCAA Tournament on Sunday in Indianapolis. Tip-off is at 5 p.m. at Bankers Life Fieldhouse on CBS. William Hill Sportsbook lists the Wolverines as two-point favorites, while the Over-Under for total points scored is 142.5 in the latest Michigan vs. Florida State odds (see up-to-date lines for every game on our college basketball odds page). 

Before making any Florida State vs. Michigan picks, you NEED to check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past four-plus years, the proprietary computer model has generated an impressive profit of $2,200 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen HUGE returns.

Now, it has set its sights on Michigan vs. Florida State. We can tell you the model is leaning Over the total, and it also says one side of the spread hits over 50 percent of the time! You ABSOLUTELY need to see it before locking in any college basketball picks.

Who wins Michigan vs. Florida State? And which side of the spread hits over 50 percent of the time? ... Join SportsLine right now to find out which side of the Michigan vs. Florida State spread you should be all over Sunday, all from the model on a roll on college basketball picks!