The Miami Marlins will look to win their second game in a row when they take on the Pittsburgh Pirates in a National League matchup on Wednesday afternoon. Miami defeated Pittsburgh 3-2 on Tuesday. The Marlins (25-40), who snapped a two-game losing streak, are 11-20 on the road this season. The Pirates (27-41), who had their four-game winning streak snapped, are 18-19 on their home field in 2025.

First pitch from PNC Park in Pittsburgh is set for 12:35 p.m. ET. Pittsburgh is a -155 favorite on the money line (risk $155 to win $100) in the latest Marlins vs. Pirates odds from DraftKings Sportsbook, while the total number of runs Vegas thinks will be scored, or the over/under, is 8.5 in the latest MLB odds. 

Before you make any Marlins vs. Pirates picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.

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The model has simulated Marlins vs. Pirates 10,000 times and the results are in. We can tell you the model is going Under on the run total, and it also says one side of the money line has all the value!

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