Mariners vs. Cubs odds, line, start time, picks, best bets for June 20 interleague matchup from proven model

The Seattle Mariners will meet the Chicago Cubs in a key interleague matchup on Friday afternoon. The Mariners (37-36), who have lost two of three, are 17-17 on the road in 2025. The Cubs (45-29), who have won three of four, are 24-13 on their home field this season.

First pitch from Wrigley Field in Chicago is set for 2:20 p.m. ET. The Cubs have won eight of the past 10 meetings with the Mariners. Chicago is a -147 favorite on the money line (risk $147 to win $100) in the latest Mariners vs. Cubs odds from FanDuel Sportsbook, while the total number of runs Vegas thinks will be scored, or the over/under, is 9.5 in the latest MLB odds. 

Before you make any Mariners vs. Cubs picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 13 of the 2025 MLB season on a 37-30 run on top-rated MLB sides picks. It has excelled making home run prop picks, returning more than 35 units of profit over the past two months. Anybody following could have seen strong returns!

The model has simulated Mariners vs. Cubs 10,000 times and the results are in. We can tell you the model is going Under on the run total, and it also says one side of the money line has all the value!

Who wins Mariners vs. Cubs, and which side of the money line has all the value? ... Join SportsLine right now to find out which side of the money line you should be all over, all from the model on a 37-30 roll on top-rated MLB picks!