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Lane Kiffin makes his return to Oxford as his No. 7 LSU Tigers take on the No. 8 Ole Miss Rebels in a highly anticipated SEC opener for both teams on Saturday night. LSU made one of the bigger opening statements of the 2026 college football season, demolishing Clemson 51-10. Ole Miss edged out Louisville 41-38 in Week 1 for one of the best games so far this early season. Claim the latest Polymarket promo code SPORTSLINE to get a $50 trading bonus after a $10 deposit:
Kickoff is set for 7:30 p.m. ET at Vaught-Hemingway Stadium in Oxford, Miss. The Tigers are at -3 in the latest LSU vs. Ole Miss odds. The over/under for total points is 58.5.
Before making any LSU vs. Ole Miss picks, check out the college football predictions from the SportsLine Projection Model.
The model simulates every FBS game 10,000 times. It is on a 33-21 run on top-rated college football money-line picks since the 2024 season, and it has been upgraded for the 2026 season to better factor in the transfer portal!
The model has simulated LSU vs. Ole Miss 10,000 times and the results are in. The model is going Under on the total, and it also says one side of the spread hits in over 60% of simulations!
So who wins LSU vs. Ole Miss, and which side of the spread hits over 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that is on a 33-21 run on top-rated CFB picks!
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