Louisville vs. Wake Forest odds, line, spread: Proven model reveals college football picks, predictions for Week 9, 2022

An ACC battle is on tap between the Louisville Cardinals and the No. 10 Wake Forest Demon Deacons at 3:30 p.m. ET on Saturday at Cardinal Stadium. Wake Forest is looking to extend its three-game winning streak following its 43-15 win over Boston College. The Demon Deacons are favored by 3.5 points in the latest Louisville vs. Wake Forest odds from Caesars Sportsbook, while the over/under is set at 64. 

Before you make any Wake Forest vs. Louisville picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, it has simulated Louisville vs. Wake Forest 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in almost 60% of simulations. You absolutely need to see it before locking in your own picks.

So who wins Louisville vs. Wake Forest? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks... If you're already a member, see the picks below!