The Louisville Cardinals look to get back into the win column against the Virginia Cavaliers at 3 p.m. ET on Saturday at Cardinal Stadium. Louisville couldn't quite complete a comeback against No. 24 Wake Forest last weekend, and lost 37-34. Meanwhile, Virginia beat Miami last Thursday for its first win in three games.

Both programs sit in the middle of their respective divisions within the ACC, and have split the last four meetings at two wins apiece over the last four years. The Cardinals are favored by 2.5 points in the latest Louisville vs. Virginia odds from Caesars Sportsbook, and the over-under is set at 66. Before you make any Virginia vs. Louisville picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,400 for $100 players on its top-rated college football picks against the spread. It also enters Week 6 of the 2021 season on a 12-4 run on all top-rated college football side picks. Anyone who has followed it has seen HUGE returns.

Now, it has simulated Louisville vs. Virginia 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Louisville vs. Virginia? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks ... If you're already a member, see the picks below!