An ACC battle is on tap between the Louisville Cardinals and the No. 7 Virginia Cavaliers at 7 p.m. ET Wednesday at KFC Yum! Center. U of L is 3-22 overall and 3-11 at home, while the Cavaliers are 19-4 overall and 5-3 on the road. Virginia is ranked second in the ACC; U of L is ranked 15th.

The Cavaliers are favored by 16 points in the latest Louisville vs. Virginia odds from Caesars Sportsbook, and the over/under is set at 127. Before you make any Virginia vs. Louisville picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. The model enters Week 15 of the season 66-38 on all-top rated college basketball picks this season, returning almost $1,700 for $100 players. Anybody who has followed it has seen huge returns.

Now, it has simulated Louisville vs. Virginia 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread has all the value. You absolutely need to see it before locking in your own picks.

So who wins Louisville vs. Virginia? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks... If you're already a member, see the picks below!