Louisville vs. Notre Dame odds, line: 2024 college basketball picks, February 21 best bets by proven model

Notre Dame will try to secure its first three-game winning streak of the season when it travels to Louisville for an ACC matchup. Tipoff is set for 7 p.m. ET on Wednesday at KFC Yum! Center. Louisville is favored by 1.5 points in the latest Louisville vs. Notre Dame odds, while the over/under is 134.5 points, per SportsLine consensus. 

Before entering any Notre Dame vs. Louisville picks, you NEED to see the NCAA Basketball predictions from the model at SportsLine.

The model simulates every Division I college basketball game 10,000 times. It enters Week 16 of the 2023-24 season on a 136-89 roll on all top-rated college basketball picks dating back to last season, returning nearly $2,500 for $100 players. It is also off to a sizzling 25-13 start on top-rated spread picks this season. Anyone following has seen HUGE returns!

The model has simulated Louisville vs. Notre Dame 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in almost 60% of simulations. You can only see the pick at SportsLine.

So who wins Louisville vs. Notre Dame? And which side of the spread hits almost 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks. If you're already a member, see the picks below!