Louisville vs. Appalachian State odds, line, spread: Proven model reveals college basketball picks, predictions for Nov 15, 2022

The Louisville Cardinals will take on the App State Mountaineers at 6 p.m. ET Tuesday at KFC Yum! Center. Louisville has lost a pair of games by exactly one point to open the season, so it will be looking for its first win in this game. The Cardinals are favored by 5.5 points in the latest Louisville vs. App State odds from Caesars Sportsbook, while the over/under is set at 137.5. 

Before you make any App State vs. Louisville picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past six-plus years, the proprietary computer model has generated more than $1,200 for $100 players on its top-rated college basketball picks against the spread. Anybody who has followed it has seen profitable returns.

Now, it has simulated Louisville vs. App State 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in almost 70% of simulations! You absolutely need to see it before locking in your own picks.

So who wins Louisville vs. App State? And which side of the spread hits almost 70% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks.